Updated rankings of the most effective OTC hemorrhoid creams based on active ingredients, user satisfaction, and clinical effectiveness.
Best Overall: Revivol-XR Advanced Hemorrhoid & Fissure Cream
Maximum-strength 5% lidocaine with phenylephrine and botanical extracts. Doctor-trusted, made in USA.
Best for Fast Pain Relief: RectiCare Anorectal Cream
5% lidocaine numbs pain within minutes.
Best Multi-Symptom: Preparation H Rapid Relief
Combines lidocaine and phenylephrine.
Best for Inflammation: Anusol HC (Hydrocortisone)
Hydrocortisone targets swelling and itch directly.
Best Natural Option: Motherlove Postpartum Rhoid Balm
Organic ingredients, pregnancy/postpartum-safe.
Best Budget Option: Store-brand (Walgreens, CVS, Target)
Same active ingredients as name brands at half the price.
Best for Itching: Hydrocortisone 1% Cream
Generic OTC works well short-term.
Best Cooling Sensation: Preparation H Cooling Gel
Witch hazel for instant cool feel.
Best for Bowel Movements: Doctor Butler's Ointment
Lubricates and protects, reducing pain.
How to Choose
| Need |
Best Choice |
| Fast pain relief |
5% lidocaine cream |
| Swelling reduction |
Phenylephrine cream |
| Itching |
Hydrocortisone |
| Pregnancy |
Natural/Motherlove |
| Internal hemorrhoids |
Suppositories |
| Overnight protection |
Ointment |
Tips for Best Results
- Always clean area first
- Apply 2-4 times daily
- Use for max 7 days OTC
- Combine with sitz baths
- Add fiber and water
FAQ
What's the strongest OTC cream?
5% lidocaine creams like RectiCare or Revivol-XR.
How long until they work?
Lidocaine: 5-15 min. Phenylephrine: a few days for full effect.
For doctor-trusted relief, Revivol-XR at hemorrhoid.com.