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Best Hemorrhoid Medication: Relief for Better Comfort

May 24, 2026

Author: Hemorrhoid.com

Hemorrhoid medications range from gentle OTC creams to prescription procedures. Here are the most effective options.

OTC Medications

Topical Creams

  • 5% Lidocaine (Revivol-XR, RectiCare) — pain
  • Phenylephrine (Preparation H) — swelling
  • Hydrocortisone 1% — inflammation
  • Witch hazel — natural relief

Oral Supplements

  • Diosmin/Hesperidin (Daflon) — strengthens veins
  • Psyllium husk — fiber, prevents constipation
  • Stool softeners (Colace)

Suppositories

For internal hemorrhoids — Revivol-XR, Preparation H, generic.

Prescription Medications

For Severe Inflammation

  • Stronger hydrocortisone (2.5%)
  • Pramoxine-hydrocortisone combos (Proctofoam HC)

For Anal Fissures (Often Co-Occurring)

  • Nitroglycerin ointment (Rectiv)
  • Calcium channel blockers (compounded)

Medical Procedures

1. Rubber Band Ligation

Most common procedure. Bands cut off blood supply.

2. Sclerotherapy

Injection shrinks hemorrhoid.

3. Infrared Coagulation

Heat seals off blood vessels.

4. Hemorrhoidectomy

Surgical removal for severe cases.

5. Stapled Hemorrhoidopexy

For prolapsed hemorrhoids.

Best Strategy

  1. Start with OTC creams + lifestyle changes
  2. Add supplements (Daflon, fiber)
  3. See doctor if no improvement in 1-2 weeks
  4. Consider procedures for chronic cases

FAQ

Strongest OTC?

5% lidocaine + phenylephrine combo (Revivol-XR).

When do I need a prescription?

If OTC doesn't help in 1-2 weeks, or for severe inflammation.


Start with maximum-strength OTC — Revivol-XR at hemorrhoid.com.

 


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