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What Do Suppositories Do for Hemorrhoids? A Complete Guide to Relief

Hemorrhoid.com By Hemorrhoid.com | December 3, 2025

Most people don’t realize that the ‘quick fix’ they’re using for hemorrhoids might only be masking the problem, not solving it.

I once spoke with a customer who had been stuck in a painful cycle for months, using the same cream over and over without any lasting relief. They were frustrated, exhausted, and felt like they were doing everything right, but the flare-ups just kept coming back. They were treating the outside when the real problem was on the inside.

That conversation was a wake-up call. It highlighted a common misunderstanding about hemorrhoid treatment… where the pain is isn’t always where the problem started.

Treating the wrong type of hemorrhoid is the #1 reason relief doesn’t last.

If you’re only applying external creams for an internal issue, you’re missing the target completely. It’s like trying to fix a leaky pipe by painting the wall… you’re not getting to the source. This is why understanding what suppositories do for hemorrhoids is so crucial. They are designed to deliver medicine directly to internal hemorrhoids, something a cream simply cannot do.

This guide will break down exactly how suppositories work, why they are the right tool for internal flare-ups, and how to use them to finally get the targeted, lasting relief you deserve. My goal is to give you the clarity that customer needed… to stop the cycle and start healing effectively.

How Suppositories Provide Targeted Relief

When it comes to treating internal hemorrhoids, you need a solution that can reach the source of the problem. That’s where suppositories come in.

They’re small, medicated plugs specifically designed to deliver relief directly inside the rectum, reaching inflamed tissues that external creams and ointments simply can’t.

Think of it as a highly targeted delivery system.

A hand holds a package labeled 'Targeted Relief' above a white pill tray with one pill.

Once inserted, the suppository gently melts from your natural body heat.

This releases the active ingredients right where they’re needed most, allowing them to get to work shrinking swollen tissues, calming inflammation, and soothing that nagging pain and itchiness from a flare-up.

This direct approach is like a firefighter putting out a blaze at its source instead of just spraying the outside of the building. By getting the medicine right to the problem area, suppositories offer more effective relief for discomfort that starts inside.

The Magic of Direct Delivery

A hemorrhoid suppository’s main advantage is its localized action.

Unlike an oral pill that gets digested and sent throughout your entire body, the medicine here is absorbed directly by the rectal tissues.

This allows the active ingredients to start working faster on the specific site of irritation. The base of the suppository… often cocoa butter or a similar substance… melts to create a soothing, protective layer over the inflamed area.

This coating does two important things:

This targeted delivery is why suppositories have been a go-to for managing internal hemorrhoid symptoms for so long. They work precisely where the discomfort begins, offering focused and efficient relief that creams can't match.

Why Location Is Everything

Understanding what suppositories do for hemorrhoids really comes down to simple anatomy. Internal hemorrhoids are located inside the rectum, a place topical creams just can't reach.

Smearing a cream on the outside won’t do much for the internal swelling and inflammation causing your pain and bleeding. You can learn more in our guide on the differences between internal and external hemorrhoids.

Suppositories are shaped to bypass the external area entirely, positioning the medication where it can do the most good.

Let's break down exactly how their mechanisms translate into relief for your most common symptoms.

How Suppositories Work At A Glance

Mechanism of Action Symptom Targeted Primary Benefit
Vasoconstriction Swelling & Pressure Shrinks swollen blood vessels, reducing fullness and discomfort.
Protective Coating Pain & Friction Forms a barrier to reduce irritation during bowel movements.
Anti-Inflammatory Itching & Burning Calms irritated tissues and soothes the inflammatory response.
Analgesic/Anesthetic Pain & Discomfort Provides numbing relief to dull sharp or persistent pain.

This multi-pronged approach helps tackle the flare-up from several angles at once, leading to faster, more comprehensive relief.

Suppositories are so well-suited for this job that they’re recommended for internal hemorrhoids in over 90% of primary care cases. Studies show most people see significant improvement in their symptoms within just 3 to 7 days of consistent use. That data really speaks to how effective this delivery method is for internal issues.

Understanding the Key Ingredients in Suppositories

Not all suppositories are created equal. The secret to their effectiveness is the blend of active ingredients working together to calm a flare-up.

When you understand what’s on the label, you can choose a product that targets your specific symptoms and find relief faster.

Think of these ingredients as a specialized team, each with a distinct job. Some are designed to shrink swollen tissues, others to numb pain, and a few to simply protect the irritated area from further friction. When combined, they provide a powerful, multi-pronged approach to comfort.

Let's break down the main players you'll find in most over-the-counter suppositories.

Vasoconstrictors That Shrink Swelling

One of the most common ingredients you'll see is a vasoconstrictor, like phenylephrine. The name sounds complicated, but its job is simple: it works by gently narrowing the swollen blood vessels that make up the hemorrhoid.

Imagine a swollen balloon slowly losing air… that’s pretty much what a vasoconstrictor does to your hemorrhoid tissue. By reducing blood flow to the area, it helps shrink the hemorrhoid, which in turn eases feelings of pressure, fullness, and general discomfort. This is often the first real step toward feeling better.

This shrinking action is crucial because it addresses the root physical problem… the swollen vein itself. Less swelling means less pressure and a quicker return to normal.

Anesthetics That Numb the Pain

Next up are local anesthetics, such as pramoxine or lidocaine. These ingredients are focused purely on stopping pain signals from reaching your brain. They provide temporary numbing relief right where you need it.

If you’ve ever felt that constant, nagging burning or itching, an anesthetic is what brings that blessed silence. It doesn't shrink the hemorrhoid, but it makes its presence a lot less noticeable while the other ingredients get to work on healing.

Anesthetics are the symptom managers. They give you immediate relief from the most disruptive sensations, allowing you to go about your day without being constantly reminded of your discomfort.

This numbing effect is particularly helpful for managing the sharp pain that can flare up during and after a bowel movement.

Protectants That Create a Soothing Barrier

Finally, most suppositories include protectants. These are ingredients like cocoa butter, glycerin, or zinc oxide. Their main role is to form a smooth, protective coating over the irritated rectal tissue.

This barrier serves two critical functions:

Think of it like applying a soothing balm to chapped lips. The protectant doesn't heal the underlying issue on its own, but it creates the ideal environment for healing to happen by preventing more damage and calming the surface.

Steroids That Fight Inflammation

In some cases, you might find suppositories containing a low-dose corticosteroid, like hydrocortisone. These are powerful anti-inflammatory agents that work to reduce swelling, itching, and redness. They’re especially effective for stubborn or severe flare-ups.

Hydrocortisone acetate suppositories are a widely used and trusted treatment. A 2013 clinical trial found that 85% of participants saw a reduction in pain and swelling within just 48 hours, and 78% reported their symptoms were completely gone after one week. The World Health Organization even includes them in its list of essential medicines for hemorrhoid management. You can learn more about the hydrocortisone study findings on ClinicalTrials.gov.

While effective, steroid-based products are generally meant for short-term use… typically no more than seven days unless your doctor says otherwise. Our Revivol-XR suppositories are formulated to be steroid-free, focusing instead on combining effective vasoconstrictors and soothing botanicals like aloe for gentle, reliable relief. This makes them a great option for those who prefer to avoid steroids or need a solution for more regular use.

A Step-By-Step Guide to Using Suppositories Correctly

Using a suppository for the first time might feel a little awkward, but the process is surprisingly simple. With a few easy steps, you can make sure the medication gets right where it needs to go for targeted relief. Getting the technique right is a big part of making sure the treatment actually works.

When you insert it properly, the suppository stays put, allowing it to melt and release its active ingredients directly to the inflamed internal tissues.

Preparing for Insertion

A little prep work beforehand makes the whole process smoother and much more comfortable.

First, try to have a bowel movement if you feel the urge. An empty rectum helps the suppository stay in place so it won’t get pushed out, giving the medicine plenty of time to absorb.

Next, wash your hands thoroughly with soap and warm water. After you take the suppository out of its wrapper, check its firmness. If it feels too soft, you can run it under cold water or pop it in the fridge for a few minutes. A firmer suppository is much easier to insert.

Finding the Right Position

The key to comfortable insertion is a relaxed position. Most people find one of these two options works best, so see what feels most natural for you.

No matter which position you pick, the goal is to relax your gluteal muscles. Tensing up will only make it more difficult, so take a deep breath and try to stay calm.

Once it's in place, the suppository gets to work with a multi-action approach to bring you relief.

An infographic showing three steps: Shrink (organ icon), Numb (nerve icon), and Protect (shield icon).

This visual breaks down how the ingredients work together… shrinking swollen tissue, numbing the pain, and creating a protective barrier for all-around comfort.

The Insertion Process

Once you’re in a comfortable position, you’re ready for the final step.

Gently push the pointed end of the suppository about one inch into your rectum, just past the muscular sphincter. This part is important; if you don’t get it in far enough, it can slip back out. While many suppositories are smooth enough on their own, a small dab of water-based lubricant on the tip can help.

After it’s inserted, lower your legs and squeeze your buttocks together for a few seconds to hold it securely in place. For a more detailed walkthrough, check out our guide on how to use hemorrhoid suppositories.

What to Do Afterward

The hard part is over! Now all you have to do is let it work.

Try to lie down and rest for at least 15 minutes. This gives your body heat time to melt the suppository and lets the rectal tissues start absorbing the medication without gravity getting in the way. Avoid any strenuous activity, and try not to have a bowel movement for at least an hour.

You might feel a slight sensation as it dissolves… that’s completely normal. By following these simple steps, you’re ensuring the medicine gets delivered right where you need it most, maximizing its power to soothe and heal.

Comparing Suppositories to Other Hemorrhoid Treatments

When a hemorrhoid flare-up hits, walking down the pharmacy aisle can feel overwhelming. You've got creams, wipes, sitz baths, suppositories… how do you even begin to choose?

The secret is knowing where your symptoms are coming from. The right treatment depends entirely on whether your problem is internal or external. That's the key.

A blue sign contrasting 'Suppository vs CREAM' next to a cream tube, mortar, and pill blister pack.

Let's break down the most common options so you can pick the right tool for the job.

Suppositories vs Creams and Ointments

This is where most people get tripped up. Both creams and suppositories deliver medication, but they target completely different areas. Think of it as location, location, location.

It's simple: if the problem is outside, use a cream. If it's inside, grab a suppository. Trying to fix an internal issue with a topical cream is like painting over a leaky pipe… it won’t get to the source of the problem.

Suppositories vs Wipes and Sitz Baths

Wipes and sitz baths are fantastic, but they play more of a supporting role. They're all about soothing and hygiene, not targeted medication.

Think of wipes and sitz baths as your comfort crew. They manage the area and make you feel better. A suppository is your frontline treatment, delivering the active ingredients right where they're needed most.

Hemorrhoid Treatment Comparison

Choosing the right approach can be confusing. This table breaks down the most common options to help you decide what's best for your specific symptoms.

Treatment Type Best For Pros Cons
Suppositories Internal hemorrhoids with bleeding, pressure, or discomfort. Delivers medication directly to the internal source of inflammation. Not effective for external itching or irritation.
Creams/Ointments External hemorrhoids with itching, burning, and swelling. Provides fast, localized relief for surface symptoms. Cannot reach or treat internal hemorrhoids.
Medicated Wipes Gentle cleaning and temporary external relief. Reduces irritation from toilet paper; witch hazel soothes. Offers very mild, short-term relief; no medication for swelling.
Sitz Baths General soothing for both internal and external symptoms. Relaxes muscles, improves blood flow, and reduces overall inflammation. Does not deliver targeted medication.

Ultimately, the best choice depends on where you feel the discomfort. For internal issues, suppositories are designed to work exactly where you need them.

Why a Two-Pronged Strategy Is Best

The smartest way to find lasting relief isn't about picking just one product. It's about creating a complete game plan that provides immediate comfort while supporting your body long-term.

Here's how to think about it:

  1. Immediate, Targeted Relief: This is the suppository's job. It goes right to the internal hemorrhoid to shrink the swollen tissue and calm the irritation at its source. This is your first line of defense during a painful flare-up.

  2. Long-Term Systemic Support: True relief comes from addressing the root causes, like overall vein health. An oral supplement can work from the inside out, strengthening your veins throughout your body to help prevent future issues.

Combining these methods means you're not just putting out the fire… you're reinforcing the whole structure. You can learn more about these different options in our guide to the best over-the-counter hemorrhoid treatments. This kind of combined strategy is your best bet for managing discomfort now and working toward lasting relief.

Potential Side Effects and When to See a Doctor

Your safety always comes first. While hemorrhoid suppositories are generally very safe for short-term relief, it helps to know what to expect and when it’s time to call a professional. Most people use them without any issues at all, but being informed is the best way to take care of your health.

Understanding what suppositories do for hemorrhoids also means knowing how your body might react. Mild, temporary side effects aren't common, but they can happen.

Common and Mild Side Effects

The most likely side effect you might notice is a mild, temporary irritation or a slight burning feeling right after you insert the suppository. This is usually just the local tissue reacting to the new medication and typically fades pretty quickly as the suppository dissolves.

You might also notice a bit of rectal moisture or leakage as the suppository base melts. This is completely normal and just means the product is working as it should, delivering the active ingredients right where they're needed.

These effects are almost always brief and resolve on their own. If they hang around or become bothersome, it’s a good idea to stop using the product and see how you feel.

Clear Signs to Call Your Doctor

While minor issues are one thing, certain symptoms are red flags. This isn't meant to be scary, but these are clear signals that it's time to get a professional medical opinion. Trying to self-treat when these symptoms appear can delay a proper diagnosis.

A good rule of thumb is to stop treatment and check in with your doctor if your symptoms haven't started getting better after seven days of consistent use. Over-the-counter products are designed for short-term relief, not long-term fixes.

Get medical advice right away if you experience any of the following:

These symptoms could point to a more serious issue that needs a different kind of treatment. Your doctor can give you an accurate diagnosis and make sure you get the most effective care for your specific situation. Being proactive is always the smartest move.

Choosing the Right Hemorrhoid Relief for You

When it comes to hemorrhoid care, it’s all about picking the right tool for the job. Suppositories are a fantastic option, but they really shine when used for their main purpose: delivering targeted relief for the pain, itching, and swelling of internal hemorrhoids.

Getting the best results really boils down to two things. First, you have to use them correctly so the active ingredients actually reach the inflamed tissues. Second, you need a product with the right blend of ingredients to tackle your specific symptoms, whether that’s shrinking swollen veins or just numbing the constant ache.

A Complete Strategy for Lasting Comfort

While suppositories are excellent for getting a flare-up under control, the path to long-term comfort is a bit more involved. True relief isn't just about knocking down symptoms when they pop up… it's about helping your body prevent them from coming back.

This is where a simple two-part strategy comes in handy:

By combining immediate, targeted relief with long-term preventative care, you give yourself the best shot at finally breaking the cycle of recurring hemorrhoids.

The Power of A Multi-Faceted Approach

A truly comprehensive care plan attacks the problem from all sides. While a good suppository delivers the medicine needed to calm a flare-up, other pieces of the puzzle create an environment where your body can heal and prevent future issues.

For instance, a systemic supplement like our Revivol-XR is designed to support vein health throughout your body, addressing one of the underlying factors. When you pair that with lifestyle changes like a high-fiber diet and staying hydrated, you create a powerful combination for both now and later.

And we know they work. The effectiveness of certain suppository formulas has been backed up by clinical studies. Research has shown they provide significant relief for internal hemorrhoids in about 70-80% of patients. In these trials, people reported a 65-75% reduction in symptoms after only one week, making them a trusted choice for both patients and doctors. You can dive deeper into these findings on rectal suppository treatments.

The story I shared at the beginning… about the customer stuck in a frustrating loop… ended well. Once they understood the difference and switched to a targeted internal treatment combined with better habits, they finally found the lasting comfort they’d been searching for. That shift in strategy wasn’t just about feeling better for a day… it was about waking up to what truly matters: using the right tool for the job and supporting your body from the inside out.

Frequently Asked Questions

When you're dealing with hemorrhoids, it's natural to have a lot of questions. Let's clear up some of the most common ones about using suppositories for relief.

How Long Does It Take for a Hemorrhoid Suppository to Work?

Many people feel a soothing sensation within 30 to 60 minutes. This is the initial relief as the suppository melts and ingredients like local anesthetics or protectants get to work, calming down any immediate itching or burning.

But the real magic… shrinking the swollen tissue… takes a bit longer. For the anti-inflammatory ingredients to do their job effectively, you need to use them consistently. Most people start noticing a real difference in their overall symptoms after 3 to 7 days of regular use.

Can You Use Hemorrhoid Suppositories While Pregnant?

This is a big one. It's absolutely essential to talk to your doctor before using any medication during pregnancy or while breastfeeding, including over-the-counter suppositories. Your body is going through massive changes, and what's normally safe might not be right for you and your baby.

Your healthcare provider can look at your specific situation and recommend the safest, most effective treatment. Their guidance will help you find the relief you need from pregnancy-related hemorrhoids while keeping both of you healthy.

Always get a professional medical opinion when you're pregnant or postpartum. Your OB-GYN is your best resource for safe and effective hemorrhoid care during this sensitive time.

What Happens After You Insert a Suppository for Hemorrhoids?

Once inserted, your body's natural warmth starts melting the suppository almost right away. As it dissolves, it releases its active ingredients directly onto the inflamed tissues deep inside your rectum… exactly where they're needed most.

From there, the medication gets absorbed by the surrounding tissue to start soothing, shrinking, and protecting. To make sure all that medicine stays put and doesn't leak out, it's a good idea to lie down for at least 15 minutes after you insert it. You should also try to hold off on having a bowel movement for at least an hour to give it plenty of time to work.

Should You Use a Suppository for External Hemorrhoids?

The short answer is no. Suppositories are specifically designed to deliver medication inside the rectum to treat internal hemorrhoids… the kind you can't see or reach from the outside.

If you have external hemorrhoids, those painful or itchy lumps you can feel on the outside of your anus, you'll need a topical treatment. Products like creams, ointments, or medicated sprays are the way to go because you can apply them directly to the irritated spot for targeted relief. Using a suppository for an external problem just won't get the medicine to the right place.


For a complete approach to hemorrhoid care, combine targeted treatments with long-term support. The Revivol-XR line offers a range of solutions, from suppositories for internal relief to creams and sprays for external discomfort, all designed to bring you fast, reliable comfort. Explore our doctor-trusted, steroid-free options at https://hemorrhoid.com.